About Sofdra
Sofdra was purposefully designed for excessive underarm sweating
Is Sofdra right for you?
Sofdra is a prescription medicine that helps reduce excessive underarm sweating in people 9 years of age and older. It goes on at bedtime and starts working while you sleep to keep you drier the next day.
How does Sofdra work?
All of us have receptors that signal when your body should sweat.
Normally, these signals will turn up and down to help control your body’s temperature (e.g, when you’re hot or while you’re exercising).
For people with excessive underarm sweating, the signal to sweat is overactive.
Meaning it will randomly turn up and make you sweat a lot, regardless of your body’s temperature.
Sofdra contains a novel molecule that targets receptors in your underarms to stop excessive sweating before it starts.
Sofdra regulates—or “turns down”— these overactive signals to better control sweat production.
Unlike antiperspirants, which just block pores that release sweat, Sofdra works by blocking the body's signal to sweat in the first place.
Sofdra is a gel formulated with your underarms in mind
- Aluminum-free
- Fragrance-free
- Gluten-free
- Paraben-free
- Propylene glycol-free
- Polyethylene glycol-free
How can Sofdra help with
excessive underarm sweating?
Sofdra was tested in two clinical studies
The studies, which included 701 people with excessive underarm sweating, were set up to measure sweat reduction with Sofdra vs placebo gel in two different ways:
- Participant questionnaire: people in the studies were asked to rate how often and how much they sweat using a validated, underarm-sweat-specific questionnaire
- Sweat production test: sweat was collected by placing a piece of filter paper in each armpit for 5 minutes. The paper was weighed before and after contact with each armpit to determine how much sweat was produced
The majority of people using Sofdra saw a significant improvement in how noticeable their sweat was and how much they sweat.
Tell me more about the results
What are the side effects of Sofdra?
Side effects were mild to moderate, and usually went away on their own
The most common side effects of Sofdra include dry mouth; blurred vision; pain, redness, swelling, itching, and irritation in the underarm area; dilation of the pupils of your eyes; and problems with urination. See more information on side effects.
Sofdra is easy to fit into your bedtime routine
Sofdra comes in a pre-dosed bottle with a convenient applicator
that's easy to use.
Indication
Sofdra (sofpironium) topical gel, 12.45% is a prescription anticholinergic medicine used on the skin to treat excessive underarm sweating (primary axillary hyperhidrosis) in adults and children 9 years of age and older.
IMPORTANT SAFETY INFORMATION
Sofdra is for use on the skin in the underarm area only. After applying Sofdra, wash your hands right away and do not touch your underarms. Sofdra is flammable. Avoid heat and flame while applying Sofdra.
Who should not use Sofdra?
Do not use Sofdra if you have certain medical conditions that can be made worse by taking an anticholinergic medicine, such as glaucoma, severe ulcerative colitis (UC) or other serious bowel problems, myasthenia gravis, and Sjogren’s syndrome.
What should I tell my healthcare provider before using Sofdra?
- Tell your healthcare provider about all of your medical conditions, including prostate, bladder or kidney problems, problems passing urine, if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if Sofdra will harm your unborn baby or pass into your breast milk.
- Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, especially any anticholinergic medicines.
What are possible side effects of Sofdra?
Serious side effects may include:
- Urinary retention. Stop using Sofdra and call your healthcare provider right away if you have difficulty urinating, urinate frequently or in a weak stream or drips, a full bladder or difficulty emptying your bladder.
- Problems with control of your body temperature. Stop using Sofdra and call your healthcare provider right away if you have decreased sweating that develops into symptoms of heat illness (e.g., hot, red skin; passing out; fast, weak pulse; fast, shallow breathing; increased body temperature).
- Blurred vision. Stop using Sofdra, call your healthcare provider right away, and do not drive or operate machinery or do hazardous work until your vision is clear.
The most common side effects of Sofdra include dry mouth; blurred vision; pain, redness, swelling, itching, and irritation in the underarm area; dilation of the pupils of your eyes; and problems with urination.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088. You may also report side effects to Botanix at 1‑866‑763‑6337.
Keep Sofdra and all medicines out of the reach of children.
Please see full Prescribing Information, Patient Product Information, and Instructions for Use.